姚后宗

电话：18070595232；微信：yhz54242056

电子邮件：yaohz@jxnu.edu.cn  

姚后宗，江西省高层次海外人才，博士，副教授，硕导，江西乐安人。主要研究方向为连续流药物化学。目前已发表25篇论文论著在Angew. Chem. Int. Ed.、Sci. Adv.、Nat. Commun.、Chem. Sci.等顶级期刊上。正主持江西省高层次海外人才引进计划、江西省自然科学基金青年基金项目、江西省教育厅科学技术研究项目重点项目、江西师范大学高层次人才（优秀海归）引进计划等项目。 

• 教育经历

   

  博士研究生：香港城市大学化学系，导师：朱光宇教授           2017/06 - 2021/10

   

  硕士研究生：苏州大学药物化学专业，导师：乔春华教授         2012/09 - 2015/06

   

  大学本科：苏州大学药学专业, 导师：乔春华教授               2008/09 - 2012/06

   

• 工作经历

   

  江西师范大学副教授、硕导，课题组组长：陈芬儿院士、袁涛教授    2023/12 - 今

   

  江西师范大学讲师、硕导，课题组组长：涂宗财教授、袁涛教授      2022/04 - 2023/11

   

  香港浸会大学研究助理，导师：吕爱平院士、张戈教授              2015/12 - 2017/05

   

• 主持的基金项目

   

  2022年江西省高层次和急需紧缺海外人才引进计划（20223BCJ25009） 30万2023/01

   

  2023年江西省自然科学基金青年基金项目（20232BAB216132）        10万2023/07 - 2026/06

   

  2022年江西省教育厅科学技术研究项目重点项目（GJJ2200308）      5万 2023/01 - 2025/12

   

  江西师范大学高层次人才（优秀海归）引进计划（12021881）        50万 2022/04 - 2027/04

   

• 发表文章

  1.王兰,^† 曾禧,^† 姚后宗,* 袁涛*. 雪层杜鹃中的黄酮类化合物及其抗氧化和抗炎活性研究. 天然产物研究与开发 2024, 

   

  2.Wang, L.^†; Zeng, X.^†; Yuan T.*; Yao H. Z.*. Nivalones C–F, four new meroterpenoids from Rhododendron nivale. Fitoterapia 2024, 176, 106017.

   

  3.Fang, J. J.^†; Yao H. Z.^†; Zhuang, C. L.*; Chen F. E*. Insight from linker investigations: Discovery of a novel phenylbenzothiazole necroptosis inhibitor targeting receptor-interacting protein kinase 1 (RIPK1) from a phenoxybenzothiazole compound with dual RIPK1/3 targeting activity. J. Med. Chem. 2023, 66, 15288-15308.

   

  4.Zeng, Q. T.; Cui, H.; Yao, H. Z.*; Yuan T*. Five sesquiterpenes from Paraconiothyrium sp. and their anti-inflammatory activity. Chem. Biodiversity 2023, e202300477.

   

  5.Deng, Z. Q.^†; Yao, H. Z.^† et al. and Zhu, G. Y. Platinum anticancer drugs: Targeting and delivery. In Bioinorganic Chemistry and Homogeneous Biomimetic Inorganic Catalysis; Pecoraro, V. L.; Guo, Z.; in Comprehensive Inorganic Chemistry III; Reedijk, J., Poeppelmeier, K. R., Eds.; Vol. 2, pp 808–846. Oxford: Elsevier. ©2023

   

  6.Yao, H. Z. et al. and Zhu, G. Y. Enhancing Circulation and Tumor Accumulation of Carboplatin via an Erythrocyte‐Anchored Prodrug Strategy. Angew. Chem. Int. Ed. 2022, 61, e202203838.

   

  7.Yao, H. Z. and Zhu, G. Y. Blood Components as Carriers for Small‐Molecule Platinum Anticancer Drugs. ChemMedChem. 2022, e202200482.

   

  8.Yao, H. Z. and Zhu, G. Y. A platinum-based fluorescent “turn on” sensor to decipher the reduction of platinum (IV) prodrugs. Dalton Trans. 2022, 51, 5394-5398. (Front Cover)

   

  9.Yao, H. Z. et al. and Zhu, G. Y. Optimization of axial ligands to promote the photoactivation of BODIPY-conjugated platinum (IV) anticancer prodrugs. Dalton Trans. 2021, 50, 13737−13747.

   

  10.Yao, H. Z. et al. and Zhu, G. Y. BODI-Pt, a green-light-activatable and carboplatin-based platinum (iv) anticancer prodrug with enhanced activation and cytotoxicity. Inorg. Chem. 2020, 59, 11823−11833. 

   

  11.Yao, H. Z. et al. and Zhu, G. Y. Synthesis and cytotoxic study of a platinum (IV) anticancer prodrug with selectivity toward luteinizing hormone-releasing hormone (LHRH) receptor-positive cancer cells. Inorg. Chem. 2019, 58, 11076−11084.

   

  12.Ni, S. J.^†; Yao, H. Z.^† et al. and Zhang, G. Chemical modifications of nucleic acid aptamers for therapeutic purposes. Int. J. Mol. Sci. 2017, 18, 1683.

   

  13.Yao, H. Z. et al. and Zhang, G. Methods to design and synthesize antibody-drug conjugates (ADCs). Int. J. Mol. Sci. 2016, 17, 194.

   

  14.Yao, H. Z. et al. and Qiao, C. H. Antischistosomal activity of N, N’-arylurea analogs against Schistosoma japonicum. Bioorg. Med. Chem. Lett. 2016, 26, 1386−1390.

   

  15.姚后宗, 尹伟, 陈晶磊, 乔春华. 一种氟代丁酸腺苷衍生物的合成. 有机化学 2014, 34, 1222−1226.