Email: qizhang@jxnu.edu.cn
张琪，江西师范大学教授，博士生导师，国家优青。主要研究兴趣为天然产物生物合成、酶催化机制、化学-酶合成和连续流合成。在Nature、Nature Chemical Biology、PNAS、Nat. Commun.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed. 等国内外著名学术刊物发表论文九十余篇。获得包括基金委优秀青年基金，国际化学生物学会-青年化学生物学家奖、美国化学会-化学结构学会奖、曙光计划、新和成化学奖、CJC新锐科学家奖等多个奖项。相关研究成果被《科学》、《美国化学化工新闻周刊》等媒体予以专文报导，并被Faculty of 1000、Nat. Prod. Rep.、Curr. Opin. Biotech. 等多个杂志予以亮点评述。兼任国际化学生物学会理事、在《Frontiers in Chemistry》、《Frontiers in Molecular Bioscience》、《Chinese Journal of Chemistry》、《Bioengineering》等多个杂志担任副主编和编委。
近几年论文：
52. Yohei Morishita,# Suze Ma,# Eugenio De La Mora,# He Li, Heng Chen, Xinjian Ji, Anthony Usclat, Patricia Amara, Yi Wei Tooh, Yvain Nicolet*, Qi Zhang*, Brandon Morinaka*. Fused radical SAM and αKG-HExxH domain proteins contain a new structural fold and catalyse cyclophane formation and β-hydroxylation. Nat. Chem. 2024, doi:10.1038/s41557-024-071482-b
51. Xinhui Li#, Xiaoyu Zhu#, Yuting Zhong, Wei Zhang, Fener Chen, Wenning Wang, Wei Ding, and Qi Zhang*. Characterization of HpnG as a purine nucleoside phosphorylase in bacteriohopanepolyol biosynthesis. Chin. J. Chem. 2024, doi:10.1002/cjoc.202400233
50. Qi Zhang*, Xiaoguang Lei*, Hang Yin*, Jianmin Yue*. Editorial: Natural product chemical biology. Bioorg Med Chem Lett. 2024, 109, 129817.
49. Suze Ma, Sijia Guo, Wei Ding*, Qi Zhang*. Daropeptide natural products. Explor Drug Sci. 2024, 2, 190–202
48. Suze Ma, Heng Chen, Shuxun Liu, Xuedong Huang, Tianlu Mo, Wan-Qiu Liu, Wei Zhang, Wei Ding, Qi Zhang*. A gene-encoded aldehyde tag repurposed from RiPP cyclophane-forming pathway. Bioorg. Med. Chem. Lett. 2024, 101, 129653
47. He Li, Wei Ding, and Qi Zhang*. Discovery and engineering of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products. RSC Chem Biol. 2024, 5, 90-108
46. Suze Ma, Wenhui Xi, Shu Wang, Heng Chen, Sijia Guo, Tianlu Mo, Wenxue Chen, Zixin Deng, Fener Chen, Wei Ding and Qi Zhang*. Substrate-Controlled Catalysis in the Ether Crosslink-Forming Radical SAM Enzymes. J. Am. Chem. Soc. 2023, 145, 22945–22953
45. Nikolaos E Labrou*, Hang Fai Kwok*, Qi Zhang*. Insights in protein biochemistry: protein biophysics 2022. Front Mol Biosci. 2023, 10, 1207184.
44. He Li, Yunjie Tu, Tao Tu*, Qi Zhang*. Immobilization of Proteases on Nanoflower-like Metal Organic Framework. Chin. J. Chem., 2023, 41, 1504-1508
43. Xinhui Li, Suze Ma, Qi Zhang*. Chemical synthesis and biosynthesis of darobactin. Tetrahedron Lett. 2023, 116, 154337
42. Leixia Chu, Jinduo Cheng, Chengzeng Zhou, Tianlu Mo, Xinjian Ji, Taoting Zhu, Jie Chen, Suze Ma, Jiangtao Gao* and Qi Zhang*. Hijacking a linaridin biosynthetic intermediate for lanthipeptide production. ACS. Chem. Biol. 2022, 17, 3198–3206.
41. Hang Fai Kwok*, Qi Zhang*. Insights in Protein Chemistry and Enzymology: 2021. Front. Mol. Biosci. 2022, 9, 944975.
40. Yuanjun Han, Suze Ma, Qi Zhang*. Substrate specificity and reaction directionality of a Three-Residue Cyclophane Forming Enzyme PauB. Chin Chem Lett. 2022, 34, 10758
39. Sijia Guo, Shu Wang, Suze Ma, Zixin Deng, Wei Ding*, Qi Zhang*. Radical SAM-dependent ether crosslinkage in daropeptide biosynthesis. Nat Commun. 2022, 13, 2361.
38. Runze Wu, Wei Ding, Qi Zhang*. Consecutive Methylation catalyzed by TsrM, an atypical Class B radical SAM methylase. Chin. J. Chem., 2022, 40, 1693-1698
37. He Li, Wei Ding and Qi Zhang*. Glucuronyl C4 dehydrogenation by the radical SAM enzyme BlsE involved in blasticidin S biosynthesis. Chem Comm, 2022, 58, 3561 - 3564
36. Jinduo Cheng, Wei Ding, Qi Zhang*. Radical SAM-Dependent Demetallation of Heme. Chin. J. Chem., 2022, 40, 1053–1058.
35. Jinduo Cheng, Wan-Qiu Liu, Xiaoyu Zhu, Qi Zhang*. Functional diversity of HemN-like Proteins. ACS Bio & Med Chem Au, 2022, 2, 109−119.
34. Suze Ma, Dhanaraju Mandalapu, Shu Wang and Qi Zhang*. Biosynthesis of cyclopropane in natural products. Nat Prod. Rep. 2022, 39, 926-945.
33. Suze Ma , Heng Chen , He Li, Xinjian Ji, Zixin Deng, Wei Ding, and Qi Zhang*. Post-translational Formation of Aminomalonate by a Promiscuous Peptide-modifying Radical SAM Enzyme. Angew Chem Int Ed. 2021, 60, 19957-19964 (Hot Paper).
32. Yue Yin, Xinjian Ji, and Qi Zhang*. The Promiscuous Activity of the Radical SAM Enzyme NosL toward Two Unnatural Substrates. Chin. J. Chem. 2021, 39, 2417-2421
31. Yunjie Tu, He Li, Tao Tu, Qi Zhang*. Lamellar Enzyme-MOF (Metal–Organic Framework) Composites Enable Catalysis on Large Substrates. CCS Chem. 2021, 3, 1198–1205
30. Jinxiu Wang, Suze Ma, Wei Ding, Tuo Chen*, Qi Zhang*. Mechanistic study of the oxidoreductase AprQ involved in the biosynthesis of the aminoglycoside antibiotic apramycin. Chin. J. Chem. 2021, 39, 1923-1926
29. Junfeng Zhao, Tianlu Mo, Xinhui Li, Wei Ding, and Qi Zhang*. Dissection of the glycosylation in the biosynthesis of the heptadecaglycoside antibiotic saccharomicin A. J. Org. Chem. 2021, 86, 11117-11124
28. Utumporn Ngivprom, Surayut Kluaiphanngam, Wenjuan Ji, Siriwalee Siriwibool, Anyanee Kamkaew, James R. Ketudat Cairns, Qi Zhang* and Rung-Yi Lai*. Characterization of NucPNP and NucV involved in the early steps of nucleocidin biosynthesis in Streptomyces calvus. RSC Adv. 2021, 11, 3510-3515
27. Jinduo Cheng, Wenjuan Ji, Suze Ma, Xinjian Ji, Zixin Deng, Wei Ding, and Qi Zhang*. Characterization and Mechanistic Study of the Radical SAM Enzyme ArsS Involved in Arsenosugar Biosynthesis. Angew Chem Int Ed 2021, 60, 7570-7575
26. Fangting Wang, Wanqing Wei, Junfeng Zhao, Tianlu Mo, Xin Wang, Xuedong Huang, Suze Ma, Shu Wang, Zixin Deng, Wei Ding, Yong Liang*, and Qi Zhang*. Genome Mining and Biosynthesis Study of a Type B Linaridin Reveals a Highly Versatile α-N-Methyltransferase. CCS Chem. 2020, 2, 1049–1057
25. Yunliang Chen, Yunpeng Yang, Xinjian Ji, Ran Zhao, Guoquan Li, Yang Gu, Aiping Shi*, Weihong Jiang*, Qi Zhang* . The SCIFF-Derived Ranthipeptides Participate in Quorum Sensing in Solventogenic Clostridia. Biotechnol. J., 2020, 15, 2000136.
24. Sueze Ma, and Qi Zhang*. Linaridin natural products. Nat. Prod. Rep. 2020, 37, 1152 – 1163
23. Junfeng Zhao, Wenjuan Ji, Xinjian Ji, and Qi Zhang*. Biochemical Characterization of an Arginine 2,3-aminomutase with Dual Substrate Specificity. Chin J Chem. 2020, 38, 959－962
22. Wenjuan Ji, Xinjian Ji, Qi Zhang, Dhanaraju Mandalapu, Zixin Deng, Wei Ding, Peng Sun, and Qi Zhang*. Sulfonium-based Homolytic Substitution Observed for the Radical SAM Enzyme HemN. Angew Chem Int Ed 2020, 59, 8880-8884
21. Wei Ding, Xinjian Ji, Yuting Zhong, Kang Xu, and Qi Zhang*. Adenosylation reactions catalyzed by the radical S-adenosylmethionine superfamily enzymes. Curr Opin Chem Biol. 2020, 55, 86-95.
20. Yuting Zhong, Xinjian Ji, Qi Zhang*. Radical SAM‐dependent adenosylation involved in bacteriohopanepolyol biosynthesis. Chin J Chem. 2019, 38, 39-42.
19. Tianlu Mo, Xinjian Ji, Wei Yuan, Dhanaraju Mandalapu, Fangting Wang, Yuting Zhong, Fuyou Li, Qin Chen, Wei Ding, Zixin Deng, Shaoning Yu,* Qi Zhang*. Thuricin Z, a narrow-spectrum sactibiotic that targets cell membrane. Angew Chem Int Ed. 2019, 58, 18793-18797.
18. Lei Liu, Stephen Chan, Tianlu Mo, Wei Ding, Shaoning Yu, Qi Zhang*, Shuguang Yuan*. Movements of the Substrate-Binding Clamp of Cypemycin Decarboxylase CypD. J Chem Inf Model. 2019, 59, 2924-2929
17. Xijian Ji, Tianlu Mo, Wan-Qiu Liu, Wei Ding, Zixin Deng, Qi Zhang*. Revisiting the Mechanism of the Anaerobic CoproporphyrinogenIII Oxidase HemN. Angew Chem Int Ed. 2019, 58, 6235-6238
16. Tianlu Mo, Hong Yuan, Fangting Wang, Suze Ma, Jinxiu Wang, Ting Li, Guangfeng Liu, Shaoning Yu*, Xiangshi Tan*, Wei Ding*, and Qi Zhang*. Convergent evolution of the Cys decarboxylases involved in aminovinyl-cysteine (AviCys) biosynthesis. FEBS Lett. 2019, 593, 573-580
15. Yujie Wu, Runze Wu, Dhanaraju Mandalapu, Tuo Chen, Wei Ding, Qi Zhang*. Radical SAM-dependent adenosylation catalyzed by L-tyrosine lyases. Org. Biomol. Chem. 2019, 17, 1809-1812.
14. Dhanaraju Mandalapu, Xinjian Ji, Qi Zhang*. Reductive cleavage of sulfoxide and sulfone by two radical S-adenosyl-L-methionine enzymes. Biochemistry 2019, 58, 36-39
13. Wei Ding, Ning Yuan, Dhanaraju Mandalapu,Tianlu Mo, Suwei Dong*, Qi Zhang*. Cypemycin decarboxylase CypD is not responsible for aminovinyl-cysteine (AviCys) ring formation. Org. Lett. 2018, 7, 7670-7673
12. Wei Ding, Tianlu Mo, Dhanaraju Mandalapu, Qi Zhang*. Substrate specificity of the cypemycin decarboxylase CypD. Synth Syst Biotechnol. 2018, 3, 159-162.
11. Xinjian Ji, Dhanaraju Mandalapu, Jinduo Chen, Wei Ding, and Qi Zhang*. Expanded chemistry of the class C radical SAM methyltransferase NosN by using an allyl analogue of SAM. Angew. Chem. Int. Ed. 2018, 57, 6601-6604.
10. Qi Zhang*, Jingyu Zhang, and Evripidis Gavathiotis*. ICBS 2017 in Shanghai-Illuminating Life with Chemical Innovation. ACS Chem. Biol., 2018, 13, 1111-1122
9. Dhanaraju Mandalapu, Xinjian Ji, Jinfeng Chen, Chuchu Guo, Wan-Qiu Liu, Wei Ding, Jiahai Zhou, Qi Zhang*. Thioesterase-Mediated Synthesis of Teixobactin Analogues: Mechanism and Substrate Specificity. J. Org. Chem. 2018, 83, 7271-7275.
8. Chuchu Guo, Dhanaraju Mandalapu, Xinjian Ji, Jiangtao Gao*, and Qi Zhang*. Chemistry and Biology of Teixobactin. Chem. Eur. J. 2018, 24, 5406-5422
7. Wan-Qiu Liu, Patricia Amara, Jean-Marie Mouesca, Xinjian Ji, Oriane Renoux, Lydie Mar-tin, Chen Zhang, Qi Zhang* and Yvain Nicolet*. 1,2-diol dehydration by the radical SAM enzyme AprD4 – a matter of proton circulation and substrate flexibility. J. Am. Chem. Soc. 2018, 140, 1365-1371
6. Wei Ding, Wenjuan Ji, Yujie Wu, Runze Wu, Wan-Qiu Liu, Tianlu Mo, Junfeng Zhao, Xiaoyan Ma, Wei Zhang, Ping Xu, Zixin Deng, Boping Tang,* Yi Yu*, and Qi Zhang*. Biosynthesis of the Nosiheptide Indole Side Ring Centers on a Cryptic Carrier Protein NosJ. Nat. Commun. 2017, 8, 437
5. Lei Liu, Xinjian Ji, Yongzhen Li, Wenjuan Ji, Tianlu Mo, Wei Ding and Qi Zhang*. A mechanistic study of the non-oxidative decarboxylation catalyzed by the radical S-adenosyl-L-methionine enzyme BlsE involved in blasticidin S biosynthesis. Chem. Commun. 2017, 53, 8952
4. Tianlu Mo, Wan-Qiu Liu, Wenjuan Ji, Junfeng Zhao, Tuo Chen, Wei Ding, Shaoning Yu*, and Qi Zhang*. Biosynthetic Insights into Linaridin Natural Products from Genome Mining and Precursor Peptide Mutagenesis. ACS Chem Biol 2017, 12, 1484-1488.
3. Wei Ding, Yujie Wu, Xinjian Ji, Haocheng Qianzhu, Fener Chen, Zixin Deng, Yi Yu, and Qi Zhang*. Nucleoside-linked Shunt Products in the Reaction Catalyzed by the Class C Radical S-Adenosylmethionine Methyltransferase NosN. Chem. Commun. 2017, 53, 5235-5238.
2. Wei Ding, Yongzhen Li, Junfeng Zhao, Xinjian Ji, Tianlu Mo, Haocheng Qianzhu, Zixin Deng, Yi Yu, Fener Chen, and Qi Zhang*. The Catalytic Mechanism of the Class C radical S-Adenosylmethionine Methyltransferase NosN. Angew. Chem. Int. Ed. 2017, 56, 3857-3861
1. Xinjian Ji and Qi Zhang*. Using Radical SAM Chemistry to Access Nucleoside-Containing Compounds. Synlett, 2017, 28, 143-147.
