研究方向 生物催化以及生物催化技术在连续流化学中的应用研究
学习工作经历 2025.11-至今 江西师范大学化材学院 讲师 硕士生导师 2023.07-2025.10 河北大学药学院 讲师，硕士生导师 2019.09-2023.06 , 四川大学, 华西药学院药物化学, 博士 2016.09-2019.03, 天津科技大学, 生物工程学院, 生物工程专业, 硕士 2012.09-2016.06 , 河北大学, 生命科学学院, 生物工程专业, 学士
代表性论文或专利 论文： [1] Xiaoping Yue, Yitong Li, Minjie Liu, Di Sang, Zedu Huang, Fener Chen. Biocatalytic Dynamic Reductive Kinetic Resolution of Aryl α-Chloro β-Keto Esters: Divergent, Stereocontrolled Synthesis of Diltiazem, Clentiazem, and Siratiazem. Chemical Communications, 2022, 58(64): 9010-9013. [2] Xiaoping Yue, Yitong Li, Di Sang, Yuan Tao, Zedu Huang, Fener Chen. Asymmetric Synthesis of Syn-Aryl-(2S,3R)-2-Chloro-3-Hydroxy Esters via an Engineered Ketoreductase-Catalyzed Dynamic Reductive Kinetic Resolution. Chinese Chemical Letters, 2023, 34(9): 108178. [3] Xiaoping Yue, Yitong Li, Lin Yang, Yuan Tao, Zedu Huang, Fener Chen. Sustainable Asymmetric Synthesis of Diltiazem Precursor Enabled by Recombinant Escherichia coli Whole Cells Co-Expressing an Engineered Ketoreductase and Glucose Dehydrogenase. Biotechnology Journal, 2024, 19(1): 2300250. [4] Xiaoping Yue, Yitong Li, Mankun Wei, Yu Duan, Lin Yang, Fener Chen. Rational Redesign of the Loop Dynamics of Carbonyl Reductase LfSDR1 to Improve Stereoselectivity for Asymmetric Synthesis of Bulky Chiral Alcohols. International Journal of Biological Macromolecules, 2024, 274: 133345. [5] Yitong Li, Yunyun Yang, Mengting Zhang, Xiaoping Yue, Rey-Ting Guo, Zedu Huang, Fener Chen. Mutagenesis of a Single Site Inverts the Stereopreference of Imine Reductase. ACS Catalysis, 2025, 15(3): 2192-2199. [6] Yi Sun, Wenxin Huang, Qigang Fan, Xiaoping Yue, Yanbing Lin, Xueyu Chen, Jun Xie, Peize Li, Shuaishuai Xing, Yang Chen, Qiong Lei, Manli Wang, Guo Geng, Depeng Zhao, Huidong Zhang. Lithium Exposure Causes Ferroptosis to Induce Unexplained Miscarriage through Non-canonical MBOAT1 Pathway. Nature Communication. 2025, 17(1): 365. [7] Yitong Li, Xiaoping Yue, Zhining Li, Zedu Huang, Fener Chen. Asymmetric Synthesis of Sterically Hindered 1-Substituted Tetrahydro β-Carbolines Enabled by Imine Reductase: Enzyme Discovery, Protein Engineering, and Reaction Development. Organic Letters, 2023, 25(8): 1285-1289. [8] Chen Hu, Minjie Liu, Xiaoping Yue, Zedu Huang, Fener Chen. Development of a Practical, Biocatalytic Synthesis of Tert-butyl (R)-3-Hydroxyl-5-Hexenoate: a Key Intermediate to the Statin Side Chain. Organic Process Research & Developmen,2020, 24(9): 1700-1706. [9] Manli Wang, Wenxin Huang, Weina Chen, Xiaoping Yue, Yi Sun, Yanbing Lin, Shuaishuai Xing, Depeng Zhao, Yanxin Wang, Geng Guo, Qigang Fan, Zhihong Zhang, Wenli Cheng, Xinying Huang, Linlin Wu, Huidong Zhang. Interactive Effects of Bisphenol F Exposure and TLR4 rs4986790 on Unexplained Miscarriage. EBioMedicine. 2025, 121:105968. [10] 岳晓平, 陈朋, 朱玥明, 曾艳, 刘汉民, 刘红彦, 王敏, 孙媛霞. 米曲霉酸性蛋白酶基因在毕赤酵母中的异源表达及酶学性质. 生物工程学报, 2019, 35(03): 415-424. 专利： [1] 陈芬儿; 黄则度; 岳晓平. (2S, 3S)-2-氯-3-羟基酯类化合物的制备方法. 2024-03-08, 中国, CN113789353B. (专利) [2] 岳晓平, 孙鑫钰, 王家乐, 蔡笑笑. 羰基还原酶突变体及其在制备(2R,3R)-2-氟-3-羟基酯类化合物中的应用. 2024-09-03, 中国, 申请号：2024112268185. [3] 陈芬儿 ,岳晓平, 王家乐, 张笑清. 一种羰基还原酶突变体及其在制备手性醇中的应用. 2026-01-29, 中国, 申请号：202610123167X.
科研项目 基于构象动力学的羰基还原酶立体选择性调控机制及理性设计研究，河北省自然科学基金青年科学基金，B2024201087，2024/1~2026/12，5万，在研，主持。
学术任职 成都学报青年编委
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