| 王振 有机化学 校聘研究员 | 邮箱：wang.zhen@jxnu.edu.cn 电话：13621218108 通讯地址:江西省南昌市高新区紫阳大道99号江西师范大学方荫楼一区3-1211F室 课题组网址：https://cndtzx.jxnu.edu.cn/CarboSyn/dsjs/list.htm |
研究方向 开发新型的糖类药物或疫苗，开展生物活性寡糖和糖缀合物的合成研究。 学习工作经历 2007.09至2011.07 郑州大学 化学系 获得学士学位 2011.09至2014.07 中国人民大学 理学院化学系 获得硕士学位 2014.07至2015.08 北京生命科学研究所 雷晓光教授实验室，研究助理职务 2015.09至2020.10 荷兰莱顿大学 化学系 获得博士学位 2020.09至2023.06 荷兰莱顿大学 化学系 博士后研究员 2023.07至今 江西师范大学 化学与材料学院 校聘研究员 代表性论文或专利 1.Wang, Z.; Overkleeft, H. S.; Marel, G. A. and Codée, J. D. C.*.Total Synthesis and Structural Studies of Zwitterionic Bacteroides fragilis Polysaccharide A1 Fragments. J. Am. Chem. Soc.2023, 145 (25), 14052-14063 2.Wang, Z.; Gimeno, A.; Lete, M.; Overkleeft, H.; van der Marel, G.; Chiodo, F.; Jiménez-Barbero, J.; Codée, J. D. C.* Synthetic Zwitterionic Streptococcus Pneumoniae Type 1 Oligosaccharides Carrying Labile O-acetyl Esters. Angew. Chem. Int. Ed.2022, doi.org/10.1002/anie.202211940 3.Wang, Z.; Overkleeft, H. S.; Marel, G. A. and Codée, J. D. C.*. Glycerol Phosphate Modification on Group A Carbohydrate Interferes with Opsonophagocytosis of Streptococcus Pyogenes.Manuscript in preparation. 4.Wang, Z.; Enotarpi, J.; Marel, G. A. Bino, L.; Adamo, R.; and Codée, J. D. C.*. Chemical Synthesis and Immunological Evaluation of Fragments of the Multiantennary Group-Specific Polysaccharide of Group B Streptococcus, JACS Au2022, 2, 1724–1735 5.Wang Z.; Chemical synthesis of fragments of streptococcal cell wall polysaccharides (PhD thesis. Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University). Supervisor(s): Codée, J.D.C.; Marel, G.A. van der. 8 October 2020. 6.Liu, W.; Yue, Z.; Wang, Z.; Li, H.; Lei, X. Syntheses of Skeletally Diverse Tetracyclic Isodon Diterpenoid Scaffolds Guided by Dienyne Radical Cyclization Logic. Org. Lett.2020, 22, 7991-7996. 7.Zhang, Q.; Gimeno, A.; Santana, D.; Wang, Z.; Valdés-Balbin, Y.; Rodríguez-Noda, L. M.; Hansen, T.; Kong, L.; Shen, M.; Overkleeft, H. S.; Vérez-Bencomo, V.; van der Marel, G.A.; Jiménez-Barbero, J.; Chiodo, F.; and Codée, J. D. C.*. Synthetic, Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure Crucial for Antibody Interaction. ACS Cent Sci.2019, 5, 1407-1416. 8.Chen, B.; Wang, Z.; Zhang, Y.; Zhao, Z.; Chen, Z.*. Silver-catalyzed Three-component Reaction of Phenyldiazoacetate with Arylamine and Imine. Chin. J. Catal.2018, 39, 1594-1598. 9.Liu, W.; Li, H.; Cai, P.J.; Wang, Z.; Yu, Z.X.; and Lei, X.*. Scalable Total Synthesis of rac-Jungermannenones B and C. Angew. Chem. Int. Ed.2016, 55, 3112-3116. 10.Hong, B.; Li, C.; Wang, Z.; Chen, J.; Li, H.; and Lei, X.*. Enantioselective Total Synthesis of (−)-Incarviatone A. J. Am. Chem. Soc.2015, 137, 11946-11949. 11.Liu, Y.F.; Wang, Z.; Shi, J.W.; Chen, B.L.; Zhao, Z.G.; and Chen, Z.*. NHC-Ag(I)-Catalyzed Three-Component 1,3-Dipolar Cycloaddition to Provide Polysubstituted Dihydro-/Tetrahydrofurans. J. Org. Chem.2015, 80, 12733-12739. 12.Wang, Z.; Wen, J.; Bi, Q.-W.; Xu, X.-Q.; Shen, Z.-Q.; Li, X.-X.; and Chen, Z.*. Oxirane Synthesis from Diazocarbonyl Compounds via NHC-Ag+ Catalysis. Tetrahedron Lett.2014, 55, 2969-2972. 13.Wen, J.; Zhu, L.; Bi, Q.; Shen, Z.; Li, X.; Li, X.; Wang, Z.; Chen, Z.*. Highly N2-Selective Coupling of 1,2,3-Triazoles with Indole and Pyrrole. Chem. Eur. J.2014, 20, 974-978. 14.Li, G.-H.; Zhou, W.; Li, X.-X.; Bi, Q.-W.; Wang, Z.; Zhao, Z.-G.; Hu, W.-X.; and Chen, Z.*. Gold Catalyzed Enantioselective Intermolecular [3+2] Dipolar Cycloaddition of N-allenyl Amides with Nitrones. Chem. Comm.2013, 49, 4770-4772. 获奖情况 2010年 三好学生奖 2025年 江西省杰出青年基金获得者 学术任职 中国生化制药工业协会糖类药物分会专家委员会委员 | ||
