卢乃浩
发布时间:2015-09-08 浏览次数:

 

卢乃浩,男,博士,副教授。20106月华中科技大学生物无机化学专业毕业获博士学位,20107月至今任江西师范大学教师。目前主持在研国家自然科学基金项目两项,已主持完成国家自然科学基金青年项目、中国博士后基金、江西省自然科学基金项目和教育厅基金各一项,江西师范大学首批青年英才人选,2015年度江西省百人远航工程人选。

研究成果已经在相关领域的国际期刊Free Radical Biol MedJ Biol Inorg ChemChem Res ToxicolArch Biochem BiophysBiochem Biophys Res Commun等发表SCI 论文20 篇,其中IF>38篇。欢迎有志于从事化学生物学研究的研究生和本科生同学加入课题组一起工作学习!联系方式:naihaolu@jxnu.edu.cn

研究方向:

(1) 有机(黄酮类、天然有机化合物,碳纳米管)、无机分子(NaNO2)与蛋白质的相互作用及其化学生物学效应;

(2) 氨基酸翻译后修饰与蛋白质结构和功能、以及疾病发生发展的关系。

近年来主持的科研项目:

1.      国家自然科学基金(31560255)血浆蛋白质在髓过氧化物酶生物降解单壁碳纳米管中影响机制的研究(50.4)  主持在研

2.      国家自然科学基金(31260216):亚硝酸钠对髓过氧化物酶催化氯化反应的抑制作用及其与老年痴呆症的关系研究(48)   主持在研

3.      国家自然科学基金(31100608):髓过氧化物酶通过催化蛋白质氯化影响糖尿病心血管并发症病理过程的研究(20)   已结题

4.      江西省自然科学基金(20114BAB204013):已结题

5.      中国博士后科学基金(2013M531557):已结题

6.      江西省教育厅科研项目(GJJ12183):已结题

发表的代表性论文:

1.      Naihao Lu*, Jiayu Li, Zhonghong Gao*. Key roles of Tyr 10 in Cu bound Aβ complexes and its relevance to Alzheimer's disease. Archives of Biochemistry and Biophysics. 2015, 584: 1-9.

2.      Naihao Lu*, Jiayu Li, Xiaoming Ren, Rong Tian, Yi-Yuan Peng*. Nitrite attenuated hypochlorous acid-mediated heme degradation in hemoglobin. Chemico-Biological Interactions. 2015, 238: 25-32.

3.      Naihao Lu*, Shiliang Xie, Jiayu Li, Rong Tian, Yi-Yuan Peng*. Myeloperoxidase-mediated oxidation targets serum apolipoprotein A-I in diabetic patients and represents a potential mechanism leading to impaired anti-apoptotic activity of high density lipoprotein. Clinica Chimica Acta. 2015, 441: 163-170.

4.      Naihao Lu*, Jiayu Li, Rong Tian, Yi-Yuan Peng*. Key roles for tyrosine 10 in Aβ-heme complexes and its relevance to oxidative stress. Chemical Research in Toxicology. 2015, 28(3): 365-372.

5.      Naihao Lu*, Jiayu Li, Rong Tian, Yi-Yuan Peng*. Key roles of Arg5, Tyr10 and His residues in Aβ-heme peroxidase: Relevance to Alzheimer's disease. Biochemical and Biophysical Research Communications. 2014, 452(3): 676-681.

6.      Naihao Lu*, Jiayu Li, Rong Tian, Yi-Yuan Peng*. Binding of human serum albumin to single-walled carbon nanotubes activated neutrophils to increase production of hypochlorous acid, the oxidant capable of degrading nanotubes. Chemical Research in Toxicology. 2014, 27(6): 1070-1077.

7.      Naihao Lu*, Jiayu Li, Yingjie He, Rong Tian, Qiang Xiao*. Nitrative modifications of α-enolase in hepatic proteins from diabetic rats: The involvement of myeloperoxidase. Chemico-Biological Interactions. 2014, 220: 12-19.

8.      Naihao Lu*, Chao Chen, Yingjie He, Rong Tian, Qiang Xiao, Yi-Yuan Peng*. The dual effects of nitrite on hemoglobin-dependent redox reactions. Nitric Oxide. 2014, 40: 1-9.

9.      Naihao Lu*, Yingjie He, Chao Chen, Rong Tian, Qiang Xiao*, Yi-Yuan Peng. Tyrosine can protect against oxidative stress through ferryl hemoglobin reduction. Toxicology in Vitro. 2014, 28(5): 847-855.

10.  Naihao Lu, Lian Yi, Qinqin Deng, Jinyang Li, Zhonghong Gao, Hailing Li*. The interaction between desferrioxamine and hemin: a potential toxicological implication. Toxicology in Vitro. 2012, 26 (5): 732-735.

11.  Naihao Lu*, Wei Chen, Jingjie Zhu, Yi-Yuan Peng*. Enhancement of nitrite on heme-induced oxidative reactions: A potential toxicological implication. Toxicology in Vitro. 2012, 26 (1): 81-85.

12.  Naihao Lu, Wei Chen, Yi-Yuan Peng*. Effects of glutathione, Trolox and desferrioxamine on hemoglobin-induced protein oxidative damage: anti-oxidant or pro-oxidant? European Journal of Pharmacology. 2011, 659 (2-3): 95-101.

13.  Naihao Lu, Puqing Chen, Qin Yang, Yi-Yuan Peng*. Anti- and pro-oxidant effects of (+)-catechin on hemoglobin-induced protein oxidative damage. Toxicology in Vitro. 2011, 25 (4): 833-838.

14.  Naihao Lu, Xueli Li, Jinyang Li, Wenjing Xu, Hailing Li, Zhonghong Gao*. Nitrative and oxidative modifications of enolase are associated with iron in iron overload rats and in vitro. Journal of Biological Inorganic Chemistry. 2011, 16(3): 481-490.

15.  Naihao Lu, Yan Zhang, Hailing Li, Zhonghong Gao*. Oxidative and nitrative modifications of α-enolase in cardiac proteins from diabetic rats. Free Radical Biology & Medicine. 2010, 48 (7): 873-881.

16.  Naihao Lu, Goufeng Zhou, Di Pei, Lian Yi, Zhonghong Gao*. Peroxynitrite and heme protein - mediated nitrative/oxidative modification of human plasma protein: The role of free radical scavenging vs. complex forming. Toxicology in Vitro. 2009, 23 (7): 1227-1233.

17.  Naihao Lu, Yan Zhang, Zhonghong Gao*. Nitrite-glucose-glucose oxidase system directly induces rat heart homogenate oxidation and tyrosine nitration: effects of some flavonoids. Toxicology in Vitro. 2009, 23 (4): 627-633.

18.  Naihao Lu, Mingyi Zhang, Hailing Li, Zhonghong Gao*. Completely different effects of desferrioxamine on hemin/nitrite/H2O2-induced bovine serum albumin nitration and oxidation. Chemical Research in Toxicology. 2008, 21(6): 1229-1234.

19.  Naihao Lu, Zhening Zhu, Xuqi Zhao, Ran Tao, Xiangliang Yang, Zhonghong Gao*. Nano titanium dioxide photocatalytic protein tyrosine nitration: a potential hazard of TiO2 on skin. Biochemical and Biophysical Research Communications. 2008, 370(4): 675-680.