丁秋平
发布时间:2017-02-22 浏览次数:

 

 

 

 

丁秋平,男,博士,特岗教授,硕士、博士、博士后合作导师,中共党员,现任化学化工学院院务委员,分管研究生招生、培养、教学等管理工作。

    联系方式:E-mail: dqpjxnu@gmail.com  实验室:方荫楼4-4410,4-4403;办公室:4-4411.

研究方向:有机合成化学,主要利用C-H活化和多组分串联策略合成具有潜在生物活性的类天然产物杂环化合物。

学习、工作经历:

20036月于江西师范大学研究生毕业并获理学硕士学位, 留校理化测试中心工作,主要从事核磁共振波谱的教学与科研工作。

2006.9起在复旦大学化学系攻读博士学位,博士导师为吴劼教授,并于20096月获得理学博士学位。随后受聘江西师大化学化工学院副教授,从事有机化学教学研究工作,并担任有机化学教研室主任。

201211月中国科学院理化技术研究所从事博士后研究工作,合作导师为吴骊珠、蒲守智教授。

2012年获批青年科学家培养对象。

20131月低职高聘为江西师范大学教授。

201312月晋升教授。

20141月起聘为江西师范大学特岗教授。

2014.08-2015.08在美国The Scripps Research Institute (TSRI),即斯克利普斯研究所从事访学工作。

科研成果2009年获礼来公司亚太地区杰出研究生论文一等奖(Eli Lilly Asia Outstanding Graduate Thesis Award)和江西省高等学校科技成果三等奖。20112013年分别获江西省高等学校科技成果二等奖。至今共申请了5项国内专利,已授权2项;在有机化学领域的国际刊物:J. Am. Chem. Soc.ACS Catal.Chem. Soc. Rev.Org. Lett.J. Org. Chem.Green Chem.Org. Biomol. Chem.TetrahedronTetrahedron Lett.SynthesisJ. Organomet. Chem.J. Comb. Chem.Adv. Synth. Catal.等发表SCI收录科学论文80余篇。ISI可检索到论文被引用总次数超过1500次。

教学情况

近年来主要承担了本科生的《有机化学》、《有机化学实验》;

硕士生的《有机化合物结构分析》、《高等有机化学》、《有机化学发展前沿与动态》;

博士研究生的《有机化学进展》等课程的教学任务。

    已毕业硕士生情况:

曹伴鹏,2011年毕业,目前在江西科技师范大学工作;

刘仙金,2012年毕业,目前在福建省宁德市产品质量检验所工作;获江西省优秀硕士毕业论文。

计华芳,2013年毕业,获江西省优秀硕士毕业论文,目前在中国科学院福建物质结构所工作;

汪丹,2014年毕业,获江西省优秀硕士毕业论文,获国家奖学金;

周小丽,2015年毕业,获江西师范大学优秀硕士毕业论文,获江西省政府奖学金。

主持项目情况:

1. 国家自然科学基金地区基金项目:基于1,3-共轭烯炔参与的串联环化及官能化反应构建含氟杂环 编号:21662017 起止年月:2017.1-2020.12 41+20.5万配套)

2. 中国博士后特别资助项目:2-芳基苯并噻唑衍生物库的组建及其抗乳腺癌活性研究 编号:2014T70617, 起止年月:2014.8-2015.1215万。

3. 国家自然科学基金地区基金项目:过渡金属催化合成具有潜在生物活性的含氟杂环化合物研究编号:21262016 起止年月:2013.1-2016.12 50+25万配套)

4. 江西省自然科学基金重点项目:氮杂环类药物中间体的合成及其生物活性研究 立项编号:20133ACB20008,起止年月:2013.8-2016.12 50万)

5. 江西省科协“远航工程”项目  8万)

6. 中国博士后基金项目:基于异腈插入的C-H键官能化反应研究 编号:2013M531556 5万)

7. 江西省教育厅重点资助项目  (主持) 具有潜在生物活性氮杂环化合物的合成研究 编号:GJJ12169 起止年月:2012.1-2013.12 5万)

8. 江西省科技厅自然科学基金:选择性合成具有潜在生物活性的含氟杂环化合物 编号:20132BAB203006 起止年月:2013.1-2014.12 (3万)

9. 江西省科技厅项目:江西省第六批青年科学家培养对象 编号:20122BCB23012  8万)

10. 国家自然科学基金青年基金项目 (主持) 项目名称:对映选择性炔丙基取代反应研究  编号:21002042,起止年月:2011.1-2013.12 19+9.5万配套

11. 江西省教育厅资助项目:绿色介质中利用串联反应合成具有潜在生物活性的化合物  编号:GJJ10387,  起止年月:2010.1-2011.6

12. 江西省自然科学基金项目:若干导向基团诱导的C-H键活化反应 编号:2009GQH0054, 起止年月:2010.1-2011.12

13. 江西师范大学博士科研启动项目:硅胶催化的有机化学反应研究  起止年月:2009.7-2012.6

14. 浙江省有机化学与皮革化工重中之重学科开放基金:对甲苯磺酰肼参与的串联反应合成苯并呋喃、苯并吡喃研究2011.1-2012.12

15. 功能有机小分子教育部重点实验室2012 年度开放课题项目:利用串联反应合成具有潜在生物活性的氮杂环化合物  2012.1-2013.12

获奖情况:

1. 2013 江西省高等学校科技成果二等奖 多样性导向合成在类天然产物合成中的应用” 排名第一

2. 2011 江西师范大学青年教师课堂教学竞赛三等奖

3. 2011 江西省高等学校科技成果二等奖 “串联反应在合成杂环化合物中的应用” 排名第一 编号: J 1102019

4. 2009年江西省高等学校科技成果三等奖 “绿色化学技术在有机合成中的应用” 排名第二 编号:J090324

5. 2009 “Eli Lilly Asia Outstanding Graduate Thesis Award” 礼来亚洲区杰出研究生论文奖一等奖 排名第一

6. 2008年陶氏化学一等奖

7. 2007年陶氏化学二等奖

    国家发明专利:

1. 异喹啉-N-氧化物的制备方法。 丁秋平,吴劼。 授权专利号: ZL 2008 1 0037115.2

2. 1,2,3,11b-四氢-[1,2]嗪并[3,2-a]异喹啉骨架化合物的制备方法 丁秋平, 吴劼。 授权专利号: ZL 2008 1 0201107.7

 

    近年来部分论文发表情况:

1. Ding, Q.; Ye, S.; Cheng, G.; Wang, P.; Farmer, M. E.; Yu, J.-Q.* J. Am. Chem. Soc. 2017139, 417-425.

2. Y. Ping, Z. Chen, Q. Ding,* Q. Zheng, Y. Lin, Y. Peng Ru-catalyzed  ortho-oxidative alkenylation of 2-arylbenzo[d]thiazoles in aqueous solution of anionic surfactant sodium dodecylbenzesulfonate (SDBS). Tetrahedron, 2017, 73, 594-603.

3. Y. Ping, Q. Ding,* Y. Peng,* Advances in CCN Bond Formation via CH Bond Activation. ACS Catal. 2016, 6, 59896005.

4. Z. Nie, Q. Ding*, Y. Peng, Synthesis of 6-aroyl phenanthridines by Fe-catalyzed oxidative radical cyclization of 2-isocyanobiphenyls with benzylic alcohols. Tetrahedron, 2016, 72, 8350-8357.

5. Wenfan Chen, Qiuping Ding,* Ziyi Nie and Yiyuan Peng* Synthesis of 2-trifluoromethylquinolines via copper-mediated intramolecular oxidative cyclization of N-(2-alkenylaryl) enamines. RSC Adv., 2016, 6, 48767.

6. Yuanyuan Ping, Qiuping Ding*, Zhaobin Chen, Yiyuan Peng. Substrate-assisted rhodium-catalyzed C-H bond cyanation of 2-arylbenzothiazoles. Journal of Organometallic Chemistry, 2016, 815-816, 59-64.

7. P. Luo, Q. Ding,* Y. Ping, J. Hu,* Regioselective ortho-trifluoromethylthiolation of 2-arylbenzo[d]thiazole via tandem substrateassisted CH iodination and trifluoromethylthiolation. Org. Biomol. Chem., 2016, 14, 2924.

8. Qiang Zheng, Qiuping Ding*, Cong Wang, Wenfan Chen, Yiyuan Peng*, Synthesis of 2-aminoquinolines via palladium-catalyzed intermolecular oxidative cyclization of 2-vinylanilines with Isocyanides. Tetrahedron, 2016, 72, 952-958.

9. Tong Liu, Qiuping Ding*, Guanyinsheng Qiu*, Jie Wu. Tandem metal-free oxidative radical 5-exo dearomative spirocyclization and ester migration: generation of 3-functionalized coumarins from alkynoates. Tetrahedron, 2016, 72, 279 -284.

10. Qiang Zheng, Qiuping Ding*, Xiuxiu Liu, Yadong Zhang, Yiyuan Peng*. Synthesis of 4-amino-2-trifluormethyl quinoline derivatives via palladium-catalyzed cascade reactions of isocyanides with N-(ortho-iodo)aryl enamines. Journal of Organometallic Chemistry, 2015, 783, 77-82.

11. Qiang Zheng, Puying Luo,* Yuqing Lin, Wenfan Chen, Xiuxiu Liu, Yadong Zhang,and Qiuping Ding*. Palladium-catalyzed intermolecular oxidative cyclization of N-aryl enamines with isocyanides through double sp2 C–H bonds cleavage: facile synthesis of 4-aminoquinoline derivatives. Organic & Biomolecular Chemistry, 2015, 13, 4657-4660.

12. Qiuping Ding,* Shujuan Yao, Qin Yang, Xiaoyan Sang, Weihua Yu, and Yiyuan Peng. A Straightforward One-Pot Synthesis of 3,4-Dihydroquinazoline-2(1H)-thione Derivatives in Aqueous Organic Solvent. Journal of Heterocyclic Chemistry, 2015, 52, 478.

13. Qiuping Ding*, Xiaoli Zhou, Shouzhi Pu*, Banpeng Cao. Rhodium-catalyzed ortho-selective C-H halogenation of 2-arylbenzo[d]thiazoles using N-halosuccinimides as halogen sources. Tetrahedron, 2015, 71, 2376-2381.

14. Tong Liu, Guanyingsheng Qiu,* Qiuping Ding,* Radical 5-exo cyclization of alkynoates with 2-oxoacetic acids for synthesis of 3-acylcoumarins Org. Chem. Front. 2015, 2, 670.

15. Q. Ding*, T. Liu, Q.Zheng, Y. Zhang, L. Long, Ling; Y. Peng*, Rh(III)-catalyzed tandem oxidative olefination-cyclization of aryl sulfonamides. RSC Advances 2014, 4, 51309-51314.

16. S. Ye, H. Wang,Q. Xiao, Q. Ding*, J. Wu*, Aminosulfonylation of Arenes, Sulfur Dioxide, and Hydrazines Cocatalyzed by Gold(III) Chloride and Palladium Acetate Advanced Synthesis & Catalysis 2014, 356, 3225-3230.

17. X. Zhou, P. Luo*, L.Long, M. Ouyang, X.Sang, Q.Ding*, Ru-catalyzed direct C-H amidation of 2-arylbenzo[d]thiazoles with sulfonyl azides. Tetrahedron. 2014, 70, 6742-6748.

18. Y. Li, Y. Lu* , G. Qiu, Q. Ding*, Copper-Catalyzed Direct Trifluoromethylation of Propiolates: Construction of Trifluoromethylated Coumarins. Organic Letters, 2014, 16, 4240-4243.

19. Y. Li, G. Li, Q. Ding*, (Trifluoromethyl)​thiolation of 2-​alkynylbenzoates: An efficient route to 4-[(trifluoromethyl)​thio]-1H-isochromen-1-ones. European Journal of Organic Chemistry, 2014, 5017-5022.

20. Y. Li, G. Qiu, Q. Ding*, J. Wu*.Synthesis of phenanthridin-6-yldiphenylphosphine oxides by oxidative cyclization of 2-​isocyanobiphenyls with diarylphosphine oxides. Tetrahedron, 2014, 70(31), 4652-4656.

21. Q. Ding, X. Zhou, R. Fan* Recent advances in dearomatization of heteroaromatic compounds. Org. Biomol. Chem. 2014, 12, 4807.

22. Q. Ding, X. Fan*, J. Wu*, Recent Developments for the Synthesis of Heterocycles Catalyzed by N-Heterocyclic Carbene. Current Organic Chemistry, 2014, 19, 700.

23. Y. Lin, P. Luo,* Q. Zheng, Y. Liu, X. Sang, Q. Ding* Efficient construction of C–S and C–N bonds via metal-free reductive coupling of Ntosylhydrazones with benzo[d]thiazole-2-thiol RSC Adv., 2014, 4, 16855-16863.

24. Q. Ding,  C. Ye, S. Pu*, B. Cao, Pd(PPh3)4-catalyzed direct ortho-fluorination of 2-arylbenzothiazoles with an electrophilic fluoride N-fluorobenzenesulfonimide (NFSI). Tetrahedron, 2014, 70, 409-416.

25. Q. Xiao, J. Sheng, Q. Ding*, J. Wu*, Facile assembly of 1-[(trifluoromethyl)thio]isoquinolines through reaction of 2-alkynylbenzaldoxime with silver (trifluoromethyl)thiolate. Eur. J. Org. Chem. 2014, 217–221.

26. Y. Li, Q. Ding,* G. Qiu,  J. Wu* Synthesis of benzosultams via an intramolecular sp2 CH bond amination reaction of o-arylbenzenesulfonamides under metal-free conditions. Org. Biomol. Chem. 2014, 12, 149-155. 

27. Q. Ding, D. Wang, P. Luo,* M. Liu, S. Pu,* L. Zhou. AgOTf-catalyzed one-pot reactions of 2-alkynylbenzaldoximes with α,β-unsaturated carbonyl compounds. Beilstein J. Org. Chem. 2013, 9, 1949-1956.

28. Q. Ding*, H. Ji, C.Ye, J. Wang, J. Wang, L. Zhou, Y. Peng * Palladium-catalyzed direct ortho-acylation through an oxidative coupling of 2-arylbenzothiazoles with benzylic alcohols Tetrahedron, 2013, 69, 8661-8667.

29.  Q. Xiao, J. Sheng, Q. Ding,* J. Wu* Silver Triflate-Palladium Chloride Cooperative Catalysis in Tandem Reaction for the Synthesis of H-Pyrazolo[5,1-a]isoquinolines Advanced Synthesis & Catalysis, 2013, 355, 2321-2326.

30. Q. Xiao, D. Zheng, Q. Ding*, J, Wu* Generation of 1-aroxyisoquinolines via a silver-catalyzed reaction of 2-alkynylbenzaldoxime with phenol in the presence of p-toluenesulfonyl chloride Tetrahedron, 2013, 69, 5119-5122.

31.  J. Wang, Z. Nie, Y.Li, S. Tan, J. Jiang, P.Jiang, Q. Ding* Pd-Catalyzed ortho-C-H acylation/cross coupling of 2-arylbenzo[d]thiazoles with aldehydes using tert-butyl hydroperoxide as oxidant J. Chem. Res. 2013, 263-267.

32. G. Qiu, Q. Ding, J. Wu* Recent advances in isocyanide insertion chemistry Chem. Soc. Rev., 2013, 42, 5257-5269.

33. Q. Ding,* H. Ji, Z. Nie, Q.Yang, Y. Peng* Palladium-Catalyzed CH Bond Functionalization/Oxidative Acyloxylation of 2-Aryl-benzo[d]thiazoles Journal of Organometallic Chemistry 2013, 739, 33-39.

34. Q. Ding, Y. Ye, R. Fan* Recent advances in phenol dearomatization and its application in complex syntheses Synthesis 2013, 45, 1-16.

35. Q. Ding,* Y. Lin, G. Ding, F. Liao, X. Sang, Y. Peng* New simple synthesis of ring-fused 4-alkyl-4H-3,1-benzothiazine-2-thiones: Direct formation from carbon disulfide and (E)-3-(2-aminoaryl)acrylates or (E)-3-(2-aminoaryl)acrylonitriles Beilstein J. Org. Chem. 2013, 9, 460–466.

36. Q. Xiao, Y. Luo, Y.Yan, Q. Ding*, J. Wu* A palladium-catalyzed reaction of 2-alkynylbromobenzene with 2-(2-alkynyl)benzenesulfonamide RSC Adv., 2013, 3, 5779–5784.

37. Q. Ding,* X. Liu, H. Wang, M. Chen, Y. Peng* Synthesis of 1,3-Dihydrobenzo[c]thiophene-imines via Tandem Reactions of o-(1-Alkynyl) benzamides and Lawesson’s Reagent Synthesis 2012, 44, 920-926.

38. Q. Ding*, D. Wang, X. Sang, Y. Lin, Y. Peng* One-pot two-step synthesis of 1-position arylated 1,3-disubstituted isoquinoline N-oxides Tetrahedron 2012, 68, 8869-8874.

39. Q. Ding*, H. Ji, D. Wang, Y. Lin, W. Yu, Y. Peng* Pd(II)-catalyzed ortho arylation of 2-arylbenzothiazoles with aryl iodides via benzothiazole-directed C–H activation. Journal of Organometallic Chemistry 2012, 711, 62-67.

40. Q. Ding,* X. Liu, J. Yu, Q. Zhang, D. Wang, B. Cao, Y. Peng*. Access to Functionalized 4-Benzylidene-4H-benzo[d][1,3]thiazines via Tandem Addition-Cyclization/Cross-Coupling Reactions Tetrahedron, 2012, 68, 3937-3941.

41. Y. Lin, X. Lei, Q.Yang, J. Yuan, Q. Ding,* J. Xu, Y. Peng* N-Heterocyclic Carbene Catalyzed One-pot Synthesis of 2,3-Diarylquinoxalines Synthesis 2012, 44, 2699-2706. (IF = 2.4)

42. L. Gao, S. Ye, Q. Ding, Z. Chen,*, J. Wu,* An efficient approach to H-pyrazolo[5,1-a]isoquinolines via a silver triflate-catalyzed reaction of N0-(2-alkynylbenzylidene)hydrazide with allenoate Tetrahedron 2012, 68, 2765-2769.

43. P. Huang, Q. Yang, Z. Chen,* Q. Ding, J. Xu, Y. Peng* Metal Cocatalyzed Tandem Alkynylative Cyclization Reaction of in Situ Formed N-Iminoisoquinolinium Ylides with Bromoalkynes via CH Bond Activation J. Org. Chem. 2012, 77, 80928098.

44. Z. Chen,* L. Gao, S. Ye, Q. Ding, J. Wu* Silver triflate–copper(II) acetate cooperative catalysis in a cascade reaction for concise synthesis of 2-carbonyl H-pyrazolo[5,1-a]isoquinolines Chem. Commun., 2012, 48, 3975–3977.

45. Q. Ding,* B. Cao, J. Yuan, X. Liu, Y. Peng* Synthesis of thioethers via metal-free reductive coupling of tosylhydrazones with thiols Org. Biomol. Chem., 2011, 9, 748–751.

46. Q. Ding,* X. Liu, B. Cao, Z. Zong, Y. Peng* Aqueous C–S cross-coupling: synthesis of 2-iminobenzo-1,3-oxathioles via CuCl2·H2O-catalyzed tandem reaction of 2-iodophenols with isothiocyanates Tetrahedron Lett. 2011, 52, 1964-1967.

47. Qiuping Ding,* Banpeng Cao, Qin Yang, Xianjin Liu, Yiyuan Peng* Iron-Catalyzed Tandem Reactions of ortho-Aminobenzenethiols with Isothiocyanates Leading to 2- Aminobenzoazoles Under Ligand- and Solvent-Free Conditions Phosphorus, Sulfur, and Silicon, 2011, 186: 1782–1789.

48. Guanyinsheng Qiu, Yi Hu, Qiuping Ding, Yiyuan Peng,* Xiangzheng Hu and Jie Wu* Synthesis of 4-methylene-4H-benzo[d][1,3]thiazines via a tandem reaction of 1-(2-alkynylphenyl)ketoximes with Lawesson’s reagent Chem. Commun., 2011, 47, 9708–9710.

49. Xiaoli Lei, Liang Gao, Qiuping Ding, Yiyuan Peng* and Jie Wu* Generation of diverse 2-pyrones via palladium-catalyzed site-selective Suzuki-Miyaura couplings of 3-bromo-4-tosyloxy-2-pyrone Org. Biomol. Chem., 2011, 9, 6265-6270.

50. Yi Hu, Qiuping Ding, Shengqing Ye, Yiyuan Peng, Jie Wu* Rapid access to 4-substituted-pyrones and 2(5H)-furanones via a palladium-catalyzed C–OH bond activation Tetrahedron, 2011, 67, 7258-7262.

51. Guanyinsheng Qiu, Qiuping Ding, Ke Gao, Yiyuan Peng, and Jie Wu* Efficient Assembly of 1-(1H-Imidazol-1-yl)-3-methylene-1H-indenes via Tandem Reaction of (2-(Alkynyl)benzylidene)malonates with Imidazoles ACS Comb. Sci. 2011, 13 (1), 13–18.

52. Qiuping Ding,* Banpeng Cao, Xianjin Liu, Zhenzhen Zong, Yi-Yuan Peng* Synthesis of 2-aminobenzothiazole via FeCl3-catalyzed tandem reaction of 2-iodoaniline with isothiocyanate in water Green Chem. 2010, 12, 1607-1610.

53. Wenying Wang, Wenying Zhong, Runxia Zhou, Jinsheng Yu, Juan Dai Qiuping Ding* Yiyuan Peng* Iron-catalyzed one-pot synthesis of 2-aminobenzothiazoles from 2-aminobenzethiols and isothiocyanates under ligand-free conditions in water    Heterocycles 2010, 81, (12), 2841-2847.

54. Qiuping Ding*, Banpeng Cao, zhenzhen zong, Yiyuan Peng Silica Gel-Promoted Tandem Addition-Cyclization Reactions of 2-alkynylbenzenamines with isothiocyanates J. Comb. Chem. 2010, 12, 370-373.

55. Guanyinsheng Qiu, Qiuping Ding, Hui Ren, Yiyuan Peng, and Jie Wu* Multicatalytic One-Pot Reaction of 1-(2-Alkynylphenyl)ketoximes for Generation of Indole Derivatives Org. Lett., 2010, 12 (18), 3975–3977.

56. Guanyinsheng Qiu, Qiuping Ding, Yiyuan Peng, Jie Wu* Synthesis of (Z)-1-benzylidene-3-(1H-indol-1-yl)-1H-indene-2,2(3H)-dicarbonitriles via three-component reaction of 2-alkynylbenzaldehyde, malononitrile, and indole Tetrahedron Lett. 2010, 51, 4391-4394.

57. Xingxin Yu, Qiuping Ding, and Jie Wu* Generation of Diverse 2H-Isoindol-1-ylphosphonates via Three-Component Reaction of 2-Alkynylbenzaldehyde, Aniline, and Phosphite J. Comb. Chem. 2010, 12 (5), 743–746.

58. Wei Gao, Yong Luo, Qiuping Ding, Yiyuan Peng, Jie Wu* An efficient route to 4-substituted coumarins, 2(5H)-furanones, and pyrones via palladium-catalyzed couplings of alkenyl tosylates with organoindium reagents Tetrahedron Lett. 2010, 51, 136-138.